Project R-8705

Harnessing dental pulp stem cells wto improve the therapeutic potential after ischemic stroke (Research)

Stroke is a severe condition defined by loss of brain function due to impaired blood flow to the brain. It is a major cause of disability and is the second leading cause of death worldwide. Modern medicine is unable to sufficiently improve the functional outcome after stroke, highlighting the urgent need for new treatments. Stem cell therapy is considered a promising approach to minimize neurological damage and enhance functional recovery. Human dental pulp stem cells (DPSCs) are ideal candidates as they have shown to enhance neural stem cell (NSC) migration and neuronal survival. In this project, we will investigated whether neurotrophic enhancement of DPSCs by genetic upregulation of a specific growth factor results in a potentiation of the therapeutic effect after ischemic injury.

01 January 2018 - 31 December 2020