Project R-8648

Interaction of regulatory T cells with cells of the central nervous system in multiple sclerosis (Research)

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). One of the first and most crucial events in MS pathogenesis is migration of immune cells to the CNS. Here, they induce irreversible neuronal damage, leading to a disturbed signal transduction to peripheral organs, resulting in the well-known disabling MS symptoms. In this study, the interaction of regulatory T cells, which are defective in MS patients, with the CNS is studied. This will result in basic mechanistic knowledge on Treg-CNS interactions, while providing new opportunities for treating MS

01 January 2018 - 31 December 2019