Project R-9055

Unravelling the mode of action of low-frequency electromagnetic stimulation in stroke (Research)

Despite the high prevalence and devastating outcome, there are only few treatment options for ischemic stroke. Our project aims to explore low-frequency electromagnetic stimulation (LF-EMS) as a new therapeutic tool for this disease. Recent data of our laboratory indicate that LF-EMS increases survival and neurological outcome in rats and gerbils subjected to severe permanent ischemic stroke. LF-EMS induced migration of endothelial cells (which align the blood vessels) and production of the important messenger molecule nitric oxide (NO) by nitric oxide synthase (NOS) in vitro. Successful repair after stroke consists of also activating other cells such as neurons, microglia and astrocytes. The aim of this project is to investigate the effect of these other cell types. In addition, we will investigate whether LF-EMS has also a beneficial effect in another type of stroke, namely hemorrraghic stroke. Insights obtained in this project will enhance our current knowledge of LF-EMS as a stroke therapy as well as aid in the clinical translation of this therapy.

01 January 2019 - 31 December 2021