Project R-10596

Identification of key molecules involved in the recruitment of pathogenic T cells into the inflamed MS brain (Research)

In multiple sclerosis (MS), T lymphocytes migrate into the central nervous system, causing an exaggerated immune response which ultimately leads to axonal damage and neurodegeneration. Our team and others have previously identified highly cytotoxic CD4+ T lymphocytes (CD4+ CTL) that correlate to MS disease worsening. In this project, we intend to identify key molecules that are essential for the infiltration of CD4+ CTL into the brain. Inhibition of these molecules is of therapeutic value to halt neurodegeneration in progressive MS, especially since it will specifically target pathogenic T cells without affecting immunosurveillance.

01 January 2020 - 31 December 2023