Project R-10658

Epstein Barr-virus and multiple sclerosis: new tricks from an old dog. Does imprinting of inflammatory monocytes provide an answer? (Research)

Multiple sclerosis (MS) is a complex disease that arises under the influence of genetic, immunological and environmental factors. Although no MS-specific virus is known, epidemiological studies have shown that the Epstein-Barr herpes virus (EBV) increases the risk of developing MS up to four times. How this virus influences the development of MS is not sufficiently known. Current research focuses on the involvement of the adaptive immune system. In this project, for the first time, we investigate whether the involvement of the innate immune system can offer a better explanation. Knowledge of this project can be important for the development of new measures to reduce the risk of developing MS, for example by developing a preventive EBV vaccine.

01 January 2020 - 31 December 2022