Project R-11127

Nicotinic modulation of brain physiology and cognition in human aging. (Research)

Acetylcholine is one of the most important neuromodulators in the human brain. It is involved in attentional processes, memory formation, and cognitive function. Disruption of cholinergic activity, particularly nicotinic transmission, can lead to cognitive decline and is associated with neuropsychiatric diseases such as schizophrenia, depression and ADHD, indicating a major role for overall health in a physiological functioning state. In this project we aim to explore the relevance of nicotinic receptor function on human brain physiology and cognition. We hypothesize that old and young smokers in nicotine-withdrawal will show reduced facilitatory plasticity and cognitive performance, which can be re-established by nicotine application. Reduced cholinergic function is related to reduced cognitive capabilities in age, therefore we predict an age-dependent heterogenous effect in the non-smoking sub-group with adverse effects on young and facilitatory effects on elderly nonsmokers. In summary, this study aims (1) to further investigate nicotinic receptor activation-related physiological processes related to cognitive functions and (2) to explore age-dependent effects of nicotinic receptor activation on physiology and cognition.

01 February 2021 - 31 December 2024