Project R-12214

Neuronal control of gut regeneration: a (r)evolutionary question? (Research)

The intestinal epithelium is constantly being regenerated (renewed) to maintain its important barrier function and to prevent pathogens and toxins from entering the body. At the same time it facilitates the absorption of nutrients, water and electrolytes. Gut function is influenced by signals from different types of intestinal cells, the intestinal flora and important nerve connections. However, the tissue dynamics during intestinal regeneration are still poorly understood, especially the communication and coordination of regenerative cues in this context. Several studies, in vertebrates and invertebrates, show that nerve activity regulates gut regeneration. However, regenerative capacity is unevenly distributed between species, and mammals draw the short straw. Therefore, studying this process in a highly regenerative animal, the flatworm Schmidtea mediterranea, can clarify the fundamental knowledge gaps about the mechanisms and cells controlling self-renewal and differentiation during intestinal regeneration. I hypothesize that, from an evolutionary perspective, the nervous system acts as a signaling hub controlling gut organization and function, and integrating signals from the gut to ensure tissue regeneration and maintain homeostasis.

01 November 2021 - 30 October 2022