Project R-14669

Cellular Senescence: an Underestimated Player in the Pathology of MS. (Research)

Cellular senescence, characterized by an inflammatory secretome, is increasingly being acknowledged to drive disease progression in age-related diseases such as Alzheimer's. Building upon promising preliminary findings, we hypothesize that senescence also underpins immune dysfunction and disease progression in MS. Using innovative state-of-the-art techniques, preclinical models, and unique MS brain samples, we aim to assess cellular senescence in the context of divergent lesion subtypes and disease stages and identify senolytics as a therapeutic tool to counter cellular senescence and disease progression in MS.

01 January 2024 - 31 December 2025