Project R-15135

Squeezing Cancer: Micro-Topographies to Decode Biological Pathways for Targeted HNSCC Therapeutics (Research)

This project aims to revolutionize cancer therapeutics by investigating the impact of biomaterial-induced micro-topographies on head and neck cancer cell (HNSCC) behavior. Using state-of-the-art genomic techniques, we will unravel biomechanical pathways influencing cancer cell proliferation, morphological changes, and epigenetic alterations. Focused on HNSCC, a highly aggressive cancer, our study will explore the potential of micro-topographies in modulating key oncogenic signaling pathways and epigenetic regulators. By integrating these insights, we seek to identify small molecules with therapeutic potential for HNSCC, addressing a critical need for innovative anti-cancer drugs. This interdisciplinary approach combines biomechanics, genomics, and computational analytics, positioning the project at the forefront of transformative cancer research with broader implications for regenerative medicine.

01 October 2024 - 30 September 2027