Project R-3650

A pathogenic role for cytotoxic CD4+CD28null T-cells in multiple sclerosis? (Research)

Chronic stimulation of T-cells leads to a loss of the co-stimulatory molecule CD28. The expansion of " CD4+CD28null T cells" is associated with several autoimmune and chronic inflammatory diseases such as rheumatoid arthritis, Graves' disease and Wegener's granulomatosis. Increased frequencies of CD4+CD28null T cells were also demonstrated in a subset of MS patients. Our research group reported that these cells are partially autoreactive, have cytotoxic properties and accumulate in active MS lesions. It is unclear which genetic and immunological factors lead to the expansion of CD4+CD28null T cells in MS and whether these cells actively contribute to disease processes in the brain. In this study, we aim to identify these factors. Results of this study may form the basis for the development of selective therapies for MS.

01 January 2012 - 31 December 2013