Health promotion and exercise

Dienstverlening

Heart disorders

A multicenter, blinded, randomized, 12-month study with parallel groups to compare the clinical and cost-effectiveness of a new hybrid exercise intervention with usual care: the PRIORITY-project (FWO-TBM |T004420N)

The current research proposal aims to implement a hybrid exercise intervention in 450 patients across the three stages of heart failure (HF) (i.e., stage A, B, and C) that are representative (in terms of stage, age, gender, and socioeconomic background) of the Flemish population, and to validate its clinical effectiveness through a one-year randomized controlled multicenter study.

We are conducting a large randomized controlled multicenter exercise study in which the number of patients is compared with a clinically relevant improvement in maximum oxygen uptake after personalized hybrid exercise therapy (i.e., a combination of supervised and home training sessions) or usual care in patients with HF stage A/B/C.

We also hypothesize that personalized exercise therapy delivered according to our hybrid exercise intervention will encourage a greater proportion of patients to adopt and maintain an active lifestyle in the long term. Finally, PRIORITY will use a machine learning approach to develop models that can identify patients who are more likely to 1) adhere to exercise therapy and 2) respond favorably to the PRIORITY exercise intervention, enabling a more personalized intervention strategy and exercise program to maximize its therapeutic effectiveness.

Dominique Hansen

Function
Gewoon Hoogleraar - Prof. dr.

Kenneth Verboven

Function
Docent - Prof. dr.
1819 RWS 2019.04.04 Inwendige Kine 11 2

COPD

Chronic obstructive pulmonary disease (COPD) and lung cancer are conditions with high mortality rates. COPD accounts for 5% of all global deaths, and lung cancer is the leading cause of cancer-related mortality. Both diseases are characterized by extrapulmonary consequences, including muscle weakness, reduced exercise tolerance, physical inactivity, and a decline in quality of life. The aim of this research, conducted in collaboration with ZOL Genk, is to gain a deeper understanding of these outcomes.

In the first study, we will compare stable COPD patients with those experiencing an acute exacerbation (AE). Patients with an AE will also be prospectively monitored during and one month after hospitalization. The goals are: (1) to investigate the prognostic value of assessing physical functioning during an AE in terms of hospitalization and mortality, and (2) to examine the impact of AE on physical functioning and symptoms.

The second study will include patients with a primary diagnosis of non-small cell lung cancer (NSCLC) who will undergo treatment. Tests will be conducted before, during, and after treatment. The research objectives are: (1) to examine physical functioning before treatment in lung cancer patients compared to healthy controls, (2) to assess changes in physical functioning and symptoms throughout the treatment process, and (3) to explore the relationship between post-treatment physical condition in lung cancer patients and comorbidities, hospitalizations, and mortality.

Evaluations in both studies will include tests to measure physical functioning (functional exercise capacity, muscle strength, balance, and physical activity) and questionnaires to assess symptoms.

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Chris Burtin

Function
Docent - Prof. dr.
Shoot Reval Proefpersonen LR 82 Spiegel

Cancer and COPD

COPD and lung cancer are diseases with high mortality rates.

COPD accounts for 5% of all deaths worldwide, and lung cancer is the leading cause of cancer-related deaths. Both diseases are characterized by extrapulmonary effects. Muscle weakness, decreased exercise tolerance, physical inactivity, and a decline in quality of life are observed in patients with COPD and lung cancer. The aim of this research, in collaboration with ZOL Genk, is to gain more insight into these outcomes.

In the first study, we will compare stable COPD patients with patients experiencing an acute exacerbation (AE). Patients with an AE will also be prospectively followed during and one month after hospitalization. The objectives are: (1) to investigate the prognostic value of assessing physical functioning during AE in terms of hospitalization and mortality, and (2) to examine the impact of AE on physical functioning and symptoms.
In the second study, we will include patients with a primary diagnosis of non-small cell lung cancer (NSCLC) who will undergo treatment. Testing will take place before, during, and after treatment.

The research objectives are: (1) to examine physical functioning before the start of treatment in lung cancer patients compared to healthy controls, (2) to investigate changes in physical functioning and symptoms during the course of treatment in lung cancer patients, and (3) to assess the relationship between physical condition after lung cancer treatment and comorbidities, hospitalizations, and mortality.

Evaluations in both studies will include tests to measure physical functioning (functional exercise capacity, muscle strength, balance, physical activity) and questionnaires to assess symptoms.

Patients treated for lung cancer sometimes experience decreased physical fitness and reduced daily physical activity.

Physical training (for physical fitness) and movement coaching (for physical activity) are scientifically supported strategies to address these issues in various forms of cancer and chronic conditions (e.g., patients with chronic lung disease). It is important to 1) adapt these existing strategies to the specific needs of lung cancer patients; 2) demonstrate that they are feasible and effective for this patient group; and 3) assess to what extent they can positively influence quality of life and symptoms.

In this study, in collaboration with Ghent University and Jessa Hospital Hasselt, we will randomly assign 126 patients with NSCLC who underwent lung surgery 3 to 9 months ago into three groups: one group will receive movement coaching (focused on the home situation), one group will participate in supervised exercise training in the hospital three times a week, and one group will receive standard medical follow-up (similar to the other two groups).

The study will investigate the extent to which these interventions positively impact physical fitness, physical activity, quality of life, and experienced symptoms, both in the short term (after 12 weeks of intervention) and in the long term (12 weeks after the intervention ends). The input of experiential experts (patients) is crucial in this study, both for fine-tuning the movement coaching intervention in a prior pilot study and for assessing feasibility afterward.

Chris Burtin

Function
Docent - Prof. dr.
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1819 RWS 2019.04.04 Inwendige Kine 03

Type 2 Diabetes & Obesity

Prevention of Heart Failure in Type 2 Diabetes through Training Intervention: The PROTECTION Study (FWO - G095221N)

The aim of this project is to investigate the independent impact of exercise volume and intensity during a 6-month exercise intervention on cardiac function in patients with type 2 diabetes mellitus (T2DM). A total of 182 patients with type 2 diabetes will be enrolled, of which 100 will be randomly assigned through sealed envelopes into 4 subgroups (different training interventions and 1 control group) in Hasselt, and 82 patients will be enrolled in a single treatment arm (exercise intervention) at KU Leuven. By combining data from 25 patients per treatment arm, it will be possible to examine the independent impact of different exercise volumes and intensities at UHasselt.
By utilizing one larger treatment arm at KU Leuven, where a larger group of patients will be studied (n=107 in total along with UHasselt), it will be possible to investigate the impact of regular physical activity, sedentary behavior, sleep, motivation, and diet (by UGent) on the clinical benefits of exercise. Outcomes include: cardiac function (including GLS), waist circumference and body weight, glycemic control (HbA1c, glucose, insulin), lipid profile (total cholesterol, HDL, LDL, free fatty acids, triglycerides), blood inflammatory markers (cytokines), peak oxygen uptake capacity and workload capacity with investigation of oxygen extraction by NIRS, physical activity, sedentary behavior, sleep, diet, and motivation.

Optimizing the Cardiometabolic Health of Pre-Adolescent Children through Physical Activity at School: The Health and Academic Performance with Happy Children (HAPCH) Project (Erasmus+ KA2)

The prevalence of overweight and obesity among children and adolescents continues to rise, despite significant efforts from (inter)national organizations and campaigns. According to clinical standards, healthy nutrition and adequate physical activity (PA) are key lifestyle factors in preventing overweight. Although children spend 5 days a week at school for 8-10 hours, they mainly spend their time sitting during classes. This presents a significant opportunity to increase PA in school environments.
The goal of this project is to implement a PA intervention at school (>45 minutes of moderate-intensity PA per day) for 500 pre-adolescent children (aged 7-12 years) in Belgium, converting sedentary learning activities into active learning activities, aiming to prevent the onset of overweight while providing improvement or maintenance of cardiometabolic health. Outcomes include: waist circumference and weight, grip strength, endurance, blood pressure, PA, nutrition, and cognition.

Kenneth Verboven

Function
Docent - Prof. dr.

Dominique Hansen

Function
Gewoon Hoogleraar - Prof. dr.
1718 RWS 2018.04.11 Rob Van Der Straaten 04

Rehabilitation for Low Back Pain

Direct Access to Physiotherapy for Acute Lower Back Pain in Belgium (The Direct-Physio Trial)

Lower back pain (LBP) is the leading cause of disability worldwide. Increasing absenteeism from work and high medical costs make the optimization of care pathways necessary. Early or direct access to physiotherapy has already led to better clinical outcomes, reduced healthcare usage, and lower costs, and has also been implemented in other European countries (e.g., the Netherlands, the United Kingdom).

Despite these positive outcomes, direct access to physiotherapy has never been studied in Belgium. Therefore, the aim of this study is to investigate the added value of direct access to physiotherapy in terms of pain, disability, and cost-effectiveness for acute LBP compared to the usual care pathway with referral from a general practitioner. In this study, 600 adults with acute LBP, lasting more than 24 hours and less than 6 weeks, will be recruited and randomly assigned to either the usual care pathway with referral from the general practitioner or the experimental pathway with direct access to physiotherapy. Primary outcomes are pain intensity, location, and disability.

Secondarily, a cost-effectiveness analysis will be conducted to outline the costs associated with acute LBP and its treatment for both the patient and society. Secondary outcomes include beliefs and cognitions related to LBP, quality of life, disability, number of flare-ups, and overall therapy effect. All outcomes will be assessed at baseline, at the end of the intervention, and at 3 months, 1 year, and 2 years after inclusion.

The results of this study will be used to optimize the care pathway for acute LBP in Belgium. The study has been approved by the Medical Ethics Committee of UHasselt (ID number CME2021/066). This research is conducted in collaboration with AXXON, KU Leuven, UAntwerpen, and UCLouvain, and is funded by RIZIV-INAMI.

Lotte Janssens

Function
Docent - Prof. dr.

Annick Timmermans

Function
Hoogleraar - Prof. dr.
Burnout Natuur

Stress Prevention

This research focuses on preventive, nature-based, and technology-supported screening and interventions related to stress (at work) and the promotion of mental well-being.


Project Examples:

Renewing in Nature for Impending Burnout: Multidisciplinary Nature-Based Prevention Program


With this project, we aim to intervene preventively in the development of burnout by detecting and addressing early stress-related complaints.

Specifically, we want to examine the impact of evidence-based multidisciplinary interventions and renewing in nature on stress-related complaints, and we will investigate the preventive influence of these interventions on the development of burnout.

Katleen Bogaerts

Function
Docent - Prof. dr.
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Stroke

The effect of an intensive exercise program on activity limitations in the acute stage of stroke in Benin.

Objective: to develop an intensive exercise program for the acute stage of stroke in Benin and to evaluate the effects of this program on activity limitations. Methodology: This doctoral project includes four studies. (1) The first study is a systematic review and meta-analysis of the methodology and effects of exercise in the first two weeks after a stroke. It is limited to RCTs published in the English or French language with no time limit. (2) The second study is a longitudinal study of current rehabilitation practice in Benin and natural recovery after a stroke. Study participants are recruited in 5 rehabilitation centers.


In addition to patient assessment, the protocol includes an overview of practices conducted by clinicians. (3) The third study will be a pilot study on the feasibility and effectiveness of an intensive rehabilitation exercise program in the acute stage of stroke in Benin. The experimental intervention consists of two intensive rehabilitation sessions of 60 minutes per day, 5 days per week, for 4 weeks (40 hours in total). (4) The final study will be a longitudinal, single-blind, randomized, controlled
to investigate the effectiveness of an intensive exercise program in the acute phase of a stroke on clinical outcome and changes in BDNF in the blood. The experimental intervention will be designed based on the results of the pilot study and the literature review, while the control intervention will be a conventional physiotherapy.

Effectiveness of community-based physical training for people with stroke in Benin.

This study aims to develop a community-based physical activity program for stroke survivors in Benin and evaluate its effects on impairment, activity limitations, participation limitations and quality of life.

This doctoral project includes four studies: (1) a systematic review and meta-analysis of a content and effectiveness of community-based rehabilitation on quality of life in stroke survivors, (2) a cross-sectional study on participation in physical activity in stroke survivors stroke in the community in Benin: synergy between motivation and modern technologies, (3) a pilot study on the feasibility and effects of a 12-week community program with the WalkWithMe application on walking performance and quality of life in stroke survivors in Benin and (4) a longitudinal, single-blind, randomized, controlled trial of the effectiveness of a WalkWithMe app program group and a community-based physical activity group on the functioning of stroke patients.

Peter Feys

Function
Prof. dr.

Dominique Hansen

Function
Prof. dr.