Dynamic Bioimaging Lab
We pave the way for novel designer drugs and screening assays by studying transient protein forms that are invisible to classical structural biology methods.
To do this, we uniquely specialise in analysing so-called fluorescence dynamics, the seemingly random fluorescence intensity fluctuations that occur when molecules (translationally) move, (rotationally) tumble or (structurally) wobble while being imaged.
Practically, we use super-sensitive commercial and home-built fluorescence microscopes, and study the structural and molecular function of proteins in cellular processes and disease. These proteins include cytoskeletal proteins, enzymes, ion channels, membrane receptors and condensating & aggregating proteins.
Feel free to take a look around on our website & contact us if you're interested in a collaboration, internship or employment.
News and upcoming events!
Mini-Symposium: "Array detectors, the future of confocal microscopy is now!"
On the occasion of the PhD defense of Mrs. Veerle Lemmens, the Dynamic Bioimaging Lab and the Advanced Optical Microscopy Centre are organizing a MiniSymposium on Array Detectors in Confocal Microscopy. Array detectors allow faster imaging, with higher signal-to-noise, better spatial resolution. Moreover, they allow studying complex molecular motion (directional flow, diffusion nears barriers,...) and, when operated in time-resolved mode, allow correlating nanosecond fluorophore properties with micro-millisecond biomolecular properties.
When: July 10, 2024
Where: Hasselt University, Campus Diepenbeek
Doctoraatspromotie Veerle Lemmens
New software UHasselt and ZEISS shows biomolecular movement in cells at the cutting edge
One-day Workshop on Biophysical Methods for Studying Protein (Mis-/Un-)Folding & Dynamics
Do you want to investigate protein folding, unfolding or misfolding pathways, but don't know which biophysical methods to choose or combine? Look no further! This One-Day Workshop will provide a great introductory overview!
We will lecture about structural biology research on chaperones, membrane proteins and other protein systems. We will dig deep into technologies such as NMR, single-molecule FRET, cryo-EM, HDEX-MS, optical tweezers and other advanced methodological pipelines that are used to study protein real-time and/or atomistic structure and dynamics. Finally, we will introduce you to multimodal and integrative methods, and explain their synergies, pros and cons.
When: September 10, 2024
Where: KU Leuven Rega Institute
ZEISS Spectral RICS
Zoom in on what biomolecules are actually doing inside cells! Thanks to a software wizard workflow and automated analysis, multicolor crosstalk-free raster image correlation spectroscopy has never been easier!
Do you want to help the biosciences with microscopy?
Whether you're a student, doing a PhD or considering a postdoctoral career, if light microscopy intrigues you then our lab can help you to become an expert in Biophotonics! Contact us for an internship or job!
In the spotlight
Advanced Optical Microscopy Centre
The Dynamic Bioimaging Lab is closely connected to UHasselt's core facility Advanced Optical Microscopy Centre. Visit the web site to discover:
- Equipment and Expertise at the AOMC
- Microscopy Events
- Lots of resources to help you with your microscopy
Contact
Dynamic Bioimaging Lab
Biomedical Research Institute, Agoralaan C (BIOMED), B3590 Diepenbeek