LEICASTED

LEICASTED - Multimodal fluorescence microscopy and nanoscopy platform.

Fluorescence microscopy and super-resolution fluorescence microscopy -nanoscopy- offers the possibility to study in a non-invasive way structures ultimately down to the nanometer scale. The ability to do so dynamically will prove to be an indispensable tool in analyzing the molecular mechanisms and organization of living as well as non-living systems. Technological advances in the microscopy field have now resulted in commercially available microscopes that allow fast imaging with light levels that do not perturb or damage the system at study which is e.g. crucial for living systems. At the same time, one needs to be able to put these super-resolution data into the context of the larger system, which requires a combination with and integration of confocal microscopy. The aimed for optical platform and the collaboration with the microscopy manufacturer Leica aims for future advances in combining maximal spatial resolution, dynamic imaging, context generation, development of quantitative imaging modes as well as tailor-made fluorescent probes. Such platform will be used to unravel the mode of operation of important research questions with societal relevance.

Keywords: Biology, Chemistry (incl. biochemistry), Biomedical sciences (incl. biochemistry)

Disciplines: Spectroscopic methods, Biophotonics

Coordination:

• Johan Hofkens (Promoter)
• Peter Dedecker (Co-promoter)
• Jelle Hendrix (Co-promoter)
• Maarten Roeffaers (Co-promoter)
• Hans Van Oosterwyck (Co-promoter)

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